Bacopa Monnieri has been used for thousands of years in India to improve memory and mental processing. Studies show that a daily supplement of the powerful brain booster enhances mental ability and decreases memory loss.
Bacopa Monnieri has been used for its brain enhancing abilities for thousands of years.
The Indian herb, Bacopa Monnieri, boasts several Nootropic ingredient characteristics
Bacopa monnieri, also known as Brahmi in India, where it has a long history of use in the Ayurvedic medicine system, is one of the few herbs with a seriously robust evidence base regarding its nootropic properties. Although it has been traditionally used in India for almost 1,400 years with the purpose of enhancing memory, it was not until the beginning of 21st century that the first published study of its effects on humans appeared.
The study was a double-blind, randomized, placebo-controlled trial with 46 participants, in which Stough and colleagues found that B. monnieri extract (300 mg) given chronically for 12 weeks inspired early information processing, verbal learning, and memory consolidation. Another study by Steven Roodenrys and his colleagues, after conducting a trial of similar design with 66 participants, reported that a daily dose of 300mg-450mg of standardized Bacopa extract improved the ability of the subjects to retain information.
During the years that followed, more studies were carried out, both in animals and in humans, with the purpose to clarify the size and the exact nature of Bacopa’s nootropic effect as well as its mechanism of action. This increased interest enabled researchers to conduct larger (and thus more robust) trials, better powered to support, or dismiss, the previously reported effects. A good example is the double-blind, randomized, placebo controlled trial by Morgan and Stevens in 2010, with 136 participants, which showed that Bacopa significantly improved memory acquisition and retention in healthy older Australians.
By that time it was more than clear that Bacopa is, indeed, a nootropic. Although the occasional study challenging this trend showed up, something to be expected in biological sciences anyway (it happens all the time even with licensed and thoroughly tested medications), the body of evidence in favor is large; this trend was reflected in what’s called “the gold standard of evidence”, a meta-analysis of randomized controlled trials: Kongkeaw and colleagues summarized the evidence of 9 clinical trials with high quality and low risk of bias, concerning a total of 519 participants, and concluded that Bacopa monnieri has the potential to improve cognition and particularly, speed of attention.
Bacopa Minnieri boosts antioxidants creating low toxicity
Several possible mechanisms of action have been proposed and it’s possible that multiple biochemical pathways are implicated at the same time. For example, research shows activity in the following domains: Anti-oxidant/neuroprotection, acetylcholinesterase inhibition, choline acetyltransferase activation, β-amyloid reduction, increased cerebral blood flow, and monoamine potentiation and modulation, which implies an effect similar to some prescription-only (and expensive) drugs. Combined with its low toxicity, which admittedly is inferred mainly from studies in animal models, Bacopa makes a promising candidate in treating debilitating disorders such as dementia.
Rock On Brain Formula Contains Bacopa Monarrieri
ROCK ON Brain Beyond contains Bacopa Monarrieri as well as many other healthy ingredients used to help support mental focus, cognitive function, memory and recall. Rock On Brain Beyond also contains other nootropic ingredients such as GABA, DMAE, Pyroglutamic Acid, and many more. For more information on Rock On Brain Beyond and the rest of the Rock On Line please visit www.werockon.com.
REFERENCES
1. Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl) 2001;156:481-4.
2. Roodenrys S, Booth D, Bulzomi S, Phipps A, Micallef C, Smoker J. Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology 2002;27:279-81.
3. Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med 2010;16:753-9.
4. Sathyanarayanan V, Thomas T, Einother SJ, Dobriyal R, Joshi MK, Krishnamachari S. Brahmi for the better? New findings challenging cognition and anti-anxiety effects of Brahmi (Bacopa monniera) in healthy adults. Psychopharmacology (Berl) 2013;227:299-306.
5. Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, Limpeanchob N, Norman Scholfield C. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol 2014;151:528-35.
6. Aguiar S, Borowski T. Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Res 2013;16:313-26.
Bacopa monnieri, also known as Brahmi in India, where it has a long history of use in the Ayurvedic medicine system, is one of the few herbs with a seriously robust evidence base regarding its nootropic properties. Although it has been traditionally used in India for almost 1,400 years with the purpose of enhancing memory, it was not until the beginning of 21st century that the first published study of its effects on humans appeared.
The study was a double-blind, randomized, placebo-controlled trial with 46 participants, in which Stough and colleagues found that B. monnieri extract (300 mg) given chronically for 12 weeks inspired early information processing, verbal learning, and memory consolidation. Another study by Steven Roodenrys and his colleagues, after conducting a trial of similar design with 66 participants, reported that a daily dose of 300mg-450mg of standardized Bacopa extract improved the ability of the subjects to retain information.
During the years that followed, more studies were carried out, both in animals and in humans, with the purpose to clarify the size and the exact nature of Bacopa’s nootropic effect as well as its mechanism of action. This increased interest enabled researchers to conduct larger (and thus more robust) trials, better powered to support, or dismiss, the previously reported effects. A good example is the double-blind, randomized, placebo controlled trial by Morgan and Stevens in 2010, with 136 participants, which showed that Bacopa significantly improved memory acquisition and retention in healthy older Australians.
By that time it was more than clear that Bacopa is, indeed, a nootropic. Although the occasional study challenging this trend showed up, something to be expected in biological sciences anyway (it happens all the time even with licensed and thoroughly tested medications), the body of evidence in favor is large; this trend was reflected in what’s called “the gold standard of evidence”, a meta-analysis of randomized controlled trials: Kongkeaw and colleagues summarized the evidence of 9 clinical trials with high quality and low risk of bias, concerning a total of 519 participants, and concluded that Bacopa monnieri has the potential to improve cognition and particularly, speed of attention.
Bacopa Minnieri boosts antioxidants creating low toxicity
Several possible mechanisms of action have been proposed and it’s possible that multiple biochemical pathways are implicated at the same time. For example, research shows activity in the following domains: Anti-oxidant/neuroprotection, acetylcholinesterase inhibition, choline acetyltransferase activation, β-amyloid reduction, increased cerebral blood flow, and monoamine potentiation and modulation, which implies an effect similar to some prescription-only (and expensive) drugs. Combined with its low toxicity, which admittedly is inferred mainly from studies in animal models, Bacopa makes a promising candidate in treating debilitating disorders such as dementia.
Rock On Brain Formula Contains Bacopa Monarrieri
ROCK ON Brain Beyond contains Bacopa Monarrieri as well as many other healthy ingredients used to help support mental focus, cognitive function, memory and recall. Rock On Brain Beyond also contains other nootropic ingredients such as GABA, DMAE, Pyroglutamic Acid, and many more. For more information on Rock On Brain Beyond and the rest of the Rock On Line please visit www.werockon.com.
REFERENCES
1. Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl) 2001;156:481-4.
2. Roodenrys S, Booth D, Bulzomi S, Phipps A, Micallef C, Smoker J. Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology 2002;27:279-81.
3. Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med 2010;16:753-9.
4. Sathyanarayanan V, Thomas T, Einother SJ, Dobriyal R, Joshi MK, Krishnamachari S. Brahmi for the better? New findings challenging cognition and anti-anxiety effects of Brahmi (Bacopa monniera) in healthy adults. Psychopharmacology (Berl) 2013;227:299-306.
5. Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, Limpeanchob N, Norman Scholfield C. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol 2014;151:528-35.
6. Aguiar S, Borowski T. Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Res 2013;16:313-26.
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